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人类胚胎中的CRISPR基因编辑导致染色体混乱

CRISPR Gene Editing in Human Embryos Wreaks Chromosome Mayhem

A suite of experiments that use the gene-editing tool CRISPR–Cas9 to modify human embryos have revealed how the process can make large, unwanted changes to the genome at or near the target site.

一系列使用基因编辑工具CRISPR-Cas9来修改人类胚胎的实验揭示了这个过程是如何对目标位置或附近的基因组进行大的、不必要的改变。

The studies were published this month on the preprint server bioRxiv, and have not yet been peer-reviewed. But taken together, they give scientists a good look at what some say is an underappreciated risk of CRISPR–Cas9 editing. Previous experiments have revealed that the tool can make ‘off target’ gene mutations far from the target site, but the nearby changes identified in the latest studies can be missed by standard assessment methods.

这项研究发表于本月的预印本服务器bioRxiv上,尚未经过同行评审。但综合起来,他们让科学家们观察到了部分人所说的CRISPR-Cas9编辑中的一个被低估的风险。以前的实验表明,这种工具可以使“非靶点”的基因突变远离靶点,但最新研究中确定,可以通过标准评估法忽略附近的变动。

“The on-target effects are more important and would be much more difficult to eliminate,” says Gaétan Burgio, a geneticist at the Australian National University in Canberra.

堪培拉澳大利亚国立大学的遗传学家Gaétan Burgio说:“靶向效应更重要,但也更难消除”。

Read more at Scientific American
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