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大规模的新基因组研究揭开了癌症形成的秘密

Massive New Genome Study Unlocks The Mysterious Secrets of How Cancers Form

A massive, decade-long study sequencing the genomes of dozens of cancers has revealed the secrets of how tumours form and may pave the way for better and more targeted treatment.

一项对数十种癌症的基因组进行了长达十年的大规模测序研究,揭示了肿瘤形成的秘密,并可能为更好、更有针对性的治疗铺平道路。

The Pan-Cancer Project brought together over 1,300 researchers globally to tackle the mammoth task of sequencing the genomes of 38 types of cancer in nearly 2,800 patients.

这个癌症项目召集了全球1300多名研究人员,以解决在近2800名患者中对38种癌症的基因组进行测序的艰巨任务。

Their work produced a host of new discoveries – from the number and location of so-called driver mutations that push cells to reproduce uncontrollably, to the surprising similarities between cancers found in different types of tissue.

他们的工作产生了大量的新发现——从驱动细胞不受控制地繁殖的所谓突变的数量和位置,到在不同类型的组织中发现的癌症之间惊人的相似性。

The results were published Thursday in nearly two dozen papers in Nature and other Nature research journals and represent the largest and most comprehensive study of whole cancer genomes ever.

研究结果周四发表在《自然》(Nature)和其他《自然》研究期刊上的近24篇论文中,是迄今为止规模最大、最全面的癌症全基因组研究。

Read more at Science Alert

翻译:SGCS翻译组

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